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Did you mean CD47 and sirp (110 results)?
SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling.
Xu C, Jin G, Wu H, Cui W, Wang YH, Manne RK, Wang G, Zhang W, Zhang X, Han F, Cai Z, Pan BS, Hsu CC, Liu Y, Zhang A, Long J, Zou H, Wang S, Ma X, Duan J, Wang B, Liu W, Lan H, Xiong Q, Xue G, Chen Z, Xu Z, Furth ME, Haigh Molina S, Lu Y, Xie D, Bian XW, Lin HK. Xu C, et al. J Clin Invest. 2022 Mar 1;132(5):e141797. doi: 10.1172/JCI141797. J Clin Invest. 2022. PMID: 35229723 Free PMC article.
A SIRPgammahi population displayed CSLC properties and transmitted the immune escape signal through sustaining CD47 expression in both SIRPgammahi and SIRPgammalo/- tumor cells. SIRPgamma bridged MST1 and PP2A to facilitate MST1 dephosphorylation, resulting in Hippo/YAP ac …
A SIRPgammahi population displayed CSLC properties and transmitted the immune escape signal through sustaining CD47 expression in bot …
The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes.
Sharp RC, Brown ME, Shapiro MR, Posgai AL, Brusko TM. Sharp RC, et al. Front Immunol. 2021 Sep 16;12:739048. doi: 10.3389/fimmu.2021.739048. eCollection 2021. Front Immunol. 2021. PMID: 34603322 Free PMC article. Review.
SCOPE OF REVIEW: In this review, we summarize the literature related to the T1D-associated risk variants in SIRPG, which include a protein-coding variant (rs6043409, G>A; A263V) and an intronic polymorphism (rs2281808, C>T), and their potential impacts on the immunor …
SCOPE OF REVIEW: In this review, we summarize the literature related to the T1D-associated risk variants in SIRPG, which include a pr …
CD47 (Cluster of Differentiation 47).
Kaur S, Isenberg JS, Roberts DD. Kaur S, et al. Atlas Genet Cytogenet Oncol Haematol. 2021;25(2):83-102. Atlas Genet Cytogenet Oncol Haematol. 2021. PMID: 34707698 Free PMC article.
CD47 is a high affinity signaling receptor for the secreted protein thrombospondin-1 (THBS1) and the counter-receptor for signal regulatory protein-alpha (SIRPA, SIRPalpha) and SIRPgamma (SIRPG). ...CD47 has additional lateral binding partners in specific cel …
CD47 is a high affinity signaling receptor for the secreted protein thrombospondin-1 (THBS1) and the counter-receptor for signal regu …
Genetic Control of Splicing at SIRPG Modulates Risk of Type 1 Diabetes.
Smith MJ, Pastor L, Newman JRB, Concannon P. Smith MJ, et al. Diabetes. 2022 Feb 1;71(2):350-358. doi: 10.2337/db21-0194. Diabetes. 2022. PMID: 34799406 Free PMC article.
Signal regulatory protein SIRPgamma (CD172G) is expressed on the surface of lymphocytes, where it acts by engaging its ligand, CD47. SIRPG, which encodes SIRPgamma, contains a nonsynonymous coding variant, rs6043409, which is significantly associated with risk for t …
Signal regulatory protein SIRPgamma (CD172G) is expressed on the surface of lymphocytes, where it acts by engaging its ligand, CD47. …
Signal regulatory proteins in the immune system.
van Beek EM, Cochrane F, Barclay AN, van den Berg TK. van Beek EM, et al. J Immunol. 2005 Dec 15;175(12):7781-7. doi: 10.4049/jimmunol.175.12.7781. J Immunol. 2005. PMID: 16339510 Review.
For each species, there appears to be a single inhibitory SIRPalpha member that, upon interaction with the "self" ligand CD47, controls "homeostatic" innate immune effector functions, such as host cell phagocytosis. The activating SIRPbeta proteins show considerable variab …
For each species, there appears to be a single inhibitory SIRPalpha member that, upon interaction with the "self" ligand CD47, contro …
SIRPgamma-CD47 Interaction Positively Regulates the Activation of Human T Cells in Situation of Chronic Stimulation.
Dehmani S, Nerrière-Daguin V, Néel M, Elain-Duret N, Heslan JM, Belarif L, Mary C, Thepenier V, Biteau K, Poirier N, Blancho G, Haspot F. Dehmani S, et al. Front Immunol. 2021 Dec 1;12:732530. doi: 10.3389/fimmu.2021.732530. eCollection 2021. Front Immunol. 2021. PMID: 34925315 Free PMC article.
SIRPgamma spatial reorganization at the immune synapse is independent of its interaction with CD47. In vitro SIRPalpha-gamma/CD47 blockade with KWAR23 impairs IFN-gamma secretion by chronically activated T cells. ...In conclusion, we have shown that T-cell interacti …
SIRPgamma spatial reorganization at the immune synapse is independent of its interaction with CD47. In vitro SIRPalpha-gamma/CD47 …
Nanocages displaying SIRP gamma clusters combined with prophagocytic stimulus of phagocytes potentiate anti-tumor immunity.
Choi Y, Nam GH, Kim GB, Kim S, Kim YK, Kim SA, Kim HJ, Lee EJ, Kim IS. Choi Y, et al. Cancer Gene Ther. 2021 Sep;28(9):960-970. doi: 10.1038/s41417-021-00372-y. Epub 2021 Aug 4. Cancer Gene Ther. 2021. PMID: 34349240
Accordingly, CD47 blockade is known to increase tumor cell phagocytosis, eliciting tumor-specific CD8(+) T-cell immunity. ...Upon delivering the clustered SIRPgamma variant, the nanocage showed enhanced CD47 binding profiles on tumor cells, thereby promoting active …
Accordingly, CD47 blockade is known to increase tumor cell phagocytosis, eliciting tumor-specific CD8(+) T-cell immunity. ...Upon del …
Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro.
Stefanidakis M, Newton G, Lee WY, Parkos CA, Luscinskas FW. Stefanidakis M, et al. Blood. 2008 Aug 15;112(4):1280-9. doi: 10.1182/blood-2008-01-134429. Epub 2008 Jun 4. Blood. 2008. PMID: 18524990 Free PMC article.
CD47 binds to signal regulatory protein (SIRP), SIRPalpha and SIRPgamma. ...We tested, therefore, whether CD47-SIRPgamma interactions affect T-cell transmigration using blocking mAb against CD47 or SIRPgamma in an in vitro flow model. ...
CD47 binds to signal regulatory protein (SIRP), SIRPalpha and SIRPgamma. ...We tested, therefore, whether CD47-SIRPgamma inter …
Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family.
Brooke G, Holbrook JD, Brown MH, Barclay AN. Brooke G, et al. J Immunol. 2004 Aug 15;173(4):2562-70. doi: 10.4049/jimmunol.173.4.2562. J Immunol. 2004. PMID: 15294972
We have expressed the extracellular region of SIRPgamma as a soluble protein and have shown that, like SIRPalpha, it binds CD47, but with a lower affinity (K(d), approximately 23 microM) compared with SIRPalpha (K(d), approximately 2 microM). mAbs specific to SIRPgamma sho …
We have expressed the extracellular region of SIRPgamma as a soluble protein and have shown that, like SIRPalpha, it binds CD47, but …
Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment.
Nettleship JE, Ren J, Scott DJ, Rahman N, Hatherley D, Zhao Y, Stuart DI, Barclay AN, Owens RJ. Nettleship JE, et al. BMC Struct Biol. 2013 Jul 4;13:13. doi: 10.1186/1472-6807-13-13. BMC Struct Biol. 2013. PMID: 23826770 Free PMC article.
SIRPgamma is expressed on T lymphocytes where it appears to be involved in the integrin-independent adhesion of lymphocytes to antigen-presenting cells. Here we describe the first full length structure of the extracellular region of human SIRPgamma. ...The FabOX117 binding …
SIRPgamma is expressed on T lymphocytes where it appears to be involved in the integrin-independent adhesion of lymphocytes to antigen …